The Journal of Organic Chemistry

Lithiation of polyhydric compounds. Salicylic acids

MC Rotger, A Costa, JM Saa

Index: Rotger, M. Carmen; Costa, Antoni; Saa, Jose M. Journal of Organic Chemistry, 1993 , vol. 58, # 15 p. 4083 - 4087

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Citation Number: 8

Abstract

Polylithiated derivatives of salicylic and oligosalicylic acids can be generated by means of the halogento-metal exchange reaction. Dehydrobromination and other byproducts can be kept to a minimum by working with the preformed lithium salts which are soluble in THF. Even base sensitive salicylic acids such as 6-bromolasalocid acid can be functionalized under these conditions.