Synthesis of distamycin A polyamides targeting G-quadruplex DNA

…, F Cuenca, M Searcey, S Neidle

Index: Moore, Michael J. B.; Cuenca, Francisco; Searcey, Mark; Neidle, Stephen Organic and Biomolecular Chemistry, 2006 , vol. 4, # 18 p. 3479 - 3488

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Citation Number: 39

Abstract

A number of amide-linked oligopyrroles based on distamycin molecules have been synthesized by solid-state methods, and their interactions with a human intramolecular G- quadruplex have been measured by a melting procedure. Several of these molecules show an enhanced ratio of quadruplex vs. duplex DNA binding compared to distamycin itself, including one with a 2, 5-disubstituted pyrrole group. Quadruplex affinity increases with ...