Nickel (II)-catalyzed carbon–carbon bond formation reaction of functionalized organozinc reagents with aromatic aldehydes

Y Fu, JX Wang, K Wang, Y Hu

Index: Fu, Ying; Wang, Jin-Xian; Wang, Kehu; Hu, Yulai Tetrahedron, 2008 , vol. 64, # 49 p. 11124 - 11128

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Citation Number: 8

Abstract

In 1978, Mukaiyama first reported that Et 2 Zn could add smoothly to benzaldehyde in the presence of aminoalcochols. 6, 6a and 6b Since then, much attention has been devoted to the reaction, 7 especially the enantioselective addition reaction 8, 8a and 8b of dialkylzinc compounds with aldehydes and ketones. However, dialkylzinc compounds are relatively stable and poorly reactive organometallic compounds. Furthermore, in most cases only one of the two alkyl ...