Synthesis and antitubercular activity of novel Schiff bases derived from D-mannitol

ML Ferreira, TRA Vasconcelos, EM de Carvalho…

Index: Ferreira, Marcelle de L.; Vasconcelos, Thatyana R.A.; de Carvalho, Erika M.; Lourenco, Maria C.S.; Wardell, Solange M.S.V.; Wardell, James L.; Ferreira, Vitor F.; de Souza, Marcus V.N. Carbohydrate Research, 2009 , vol. 344, # 15 p. 2042 - 2047

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Citation Number: 33

Abstract

Six Schiff base derivatives of d-mannitol, 1, 6-dideoxy-1, 6-bis-{[(E)-arylmethylidene] amino}- d-mannitol (6: aryl= XC6H4: X= o-, m-and p-Cl or NO2), have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv using the Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC) in μg/mL. All three nitro derivatives exhibit significant ...