Imidate–Phosphanes as Highly Versatile N, P Ligands and Their Application in Palladium??Catalyzed Asymmetric Allylic Alkylation Reactions

…, E Van der Eycken, J Van der Eycken

Index: Noel, Timothy; Bert, Katrien; Van Der Eycken, Erik; Van Der Eycken, Johan European Journal of Organic Chemistry, 2010 , # 21 p. 4056 - 4061

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Citation Number: 12

Abstract

Abstract Chiral imidate–phosphanes were developed as a new type of N, P ligands. These ligands are easily accessible through a one-step procedure starting from a commercially available chiral aminophosphane and an imidate precursor. Excellent performance of the catalyst system was observed with various carbon nucleophiles in the Pd 0-catalyzed asymmetric allylic alkylation (up to 99% yield and> 99% ee). Moreover, good to excellent ...