NAD (P) H??Independent Asymmetric C C Bond Reduction Catalyzed by Ene Reductases by Using Artificial Co??substrates as the Hydrogen Donor

CK Winkler, D Clay, M Entner, M Plank…

Index: Winkler, Christoph K.; Clay, Dorina; Entner, Marcello; Plank, Markus; Faber, Kurt Chemistry - A European Journal, 2014 , vol. 20, # 5 p. 1403 - 1409

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Citation Number: 4

Abstract

Abstract To develop a nicotinamide-independent single flavoenzyme system for the asymmetric bioreduction of C [DOUBLE BOND] C bonds, four types of hydrogen donor, encompassing more than 50 candidates, were investigated. Six highly potent, cheap, and commercially available co-substrates were identified that (under the optimized conditions) resulted in conversions and enantioselectivities comparable with, or even superior to, ...