The Role of the Alcohol and Carboxylic Acid in Directed Ruthenium??Catalyzed C (sp3) H α??Alkylation of Cyclic Amines
SD Bergman, TE Storr, H Prokopcová…
Index: Bergman, Sheba D.; Storr, Thomas E.; Prokopcova, Hana; Aelvoet, Karel; Diels, Gaston; Meerpoel, Lieven; Maes, Bert U. W. Chemistry - A European Journal, 2012 , vol. 18, # 33 p. 10393 - 10398
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Citation Number: 29
Abstract
Abstract A general directed Ru-catalyzed C (sp 3)[BOND] H α-alkylation protocol for piperidines (less-reactive substrates than the corresponding five-membered cyclic amines) has been developed. The use of a hindered alcohol (2, 4-dimethyl-3-pentanol) as the solvent and catalyst activator, and a catalytic amount of trans-1, 2-cyclohexanedicarboxylic acid is necessary to achieve a high conversion to product. This protocol was used to ...
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