Microwave??promoted piperidination of halopyridines: a comparison between Ullmann, Buchwald–Hartwig and uncatalysed SNAr reactions

RS Yaunner, JC Barros…

Index: Yaunner, Ricardo S.; Barros, Jose C.; Da Silva, Joaquim F. M. Applied Organometallic Chemistry, 2012 , vol. 26, # 6 p. 273 - 276

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Abstract

Heteroaromatic amines are present in several biologically active compounds in addition to being versatile building blocks.[1, 2] We are particularly interested in the synthesis of aminopyridines analogous to prazosin for a study on the mechanism of action of Transport-P ligands.[3–5] Aminopyridines are usually prepared from halopyridines and amines by nucleophilic aromatic substitution (SNAr)[6] or by transition metal-mediated protocols like ...

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