Pyrido [3, 4-e]-1, 2, 4-triazines and related heterocycles as potential antifungal agents

MF Reich, PF Fabio, VJ Lee, NA Kuck…

Index: Reich; Fabio; Lee; Kuck; Testa Journal of Medicinal Chemistry, 1989 , vol. 32, # 11 p. 2474 - 2485

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Citation Number: 60

Abstract

Figure 1. prepared in either of two ways. Method A involved formation of 4-hydrazino-3- nitropyridine (4) and subsequent reaction with an acid chloride (5). Method B utilized direct reaction of 3 with an acylhydrazine (6). The choice of route A or B depended upon the commercial availability of 5 and 6. The nitro group in 7 was rapidly reduced to the amine 8 over a palladium catalyst. Ring closure was then effected with ethanolic HC1 to give the ...