Carbonic anhydrase inhibitors: inhibition of cytosolic isozymes I and II with sulfamide derivatives

A Casini, JY Winum, JL Montero, A Scozzafava…

Index: Casini, Angela; Winum, Jean-Yves; Montero, Jean-Louis; Scozzafava, Andrea; Supuran, Claudiu T. Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 5 p. 837 - 840

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Citation Number: 61

Abstract

A novel class of effective CAIs has been identified, starting from a very weak carbonic anhydrase inhibitor (CAI), sulfamide, whose X-ray crystal structure in the adduct with hCA II has recently been reported. A series of N, N-disubstituted-and N-substituted-sulfamides were prepared from the corresponding amines and N-(tert-butoxycarbonyl)-N-[4-( dimethylazaniumylidene)-1, 4-dihydropyridin-1-ylsulfonyl] azanide or the unstable N-(tert- ...