Microwave-assisted synthesis of substituted pyrazoles and pyrazolo [3, 4-d] thiopyrimidines

…, N Seifi, HA Oskooie, R Hekmatshoar

Index: Heravi, Majid M.; Nami, Navabeh; Seifi, Nasim; Oskooie, Hossein A.; Hekmatshoar, Rahim Phosphorus, Sulfur and Silicon and the Related Elements, 2006 , vol. 181, # 3 p. 591 - 599

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Citation Number: 6

Abstract

Ethyl (ethoxymethylene) cyanoacetate and ethoxymethylene malononitrile were synthesized from the reaction of malononitrile or ethylcyanoacetate with triethyl orthoformate or orthoacetate in N, N-dimethylacetamide under microwave irradiation. In a similar manner, substituted pyrazoles were synthesized from the reaction of ethyl (ethoxymethylene) cyanoacetate and ethoxymethylene malononitrile with phenylhydrazine. These pyrazoles ...