Tetrahedron Letters

Dithio-phospholipids for oriented immobilization of proteins to gold surfaces

G Kada, CK Riener, HJ Gruber

Index: Kada, Gerald; Riener, Christian K.; Gruber, Hermann J. Tetrahedron Letters, 2001 , vol. 42, # 14 p. 2677 - 2680

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Citation Number: 10

Abstract

We report the syntheses of phospholipids containing a dithio-group on their hydrophobic end and a choline or a biotin-group on their hydrophilic end. As demonstrated by surface plasmon resonance, a monolayer of these dithiolipids on gold affords specific binding of streptavidin and of biotinylated molecules in further steps.