Leaching of 2??(2??hydroxyethylmercapto) benzothiazole into contents of disposable syringes

MC Petersen, J Vine, JJ Ashley…

Index: Petersen; Vine; Ashley; Nation Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 10 p. 1139 - 1143

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Citation Number: 39

Abstract

Abstract A contaminant was found to leach into the contents of two brands of disposable syringes. It was identified as 2-(2-hydroxyethyl-mercapto) benzothiazole and is believed to be formed during manufacture of the syringes as a result of a reaction between 2- mercaptobenzothiazole, a rubber vulcanization accelerator, and ethylene oxide, used for sterilization. The contaminant was isolated from the rubber plunger-seal and identified ...