Synthesis and hydrazinolysis of β-(1, 3, 4-oxadiazol-2-yl) pyridines

OU Nesterova, AS Pugachova, MV Voevudsky…

Index: Nesterova; Pugachova; Voevudsky; Krischik; Musatov Chemistry of Heterocyclic Compounds, 2011 , vol. 46, # 12 p. 1520 - 1526

Full Text: HTML

Citation Number: 0

Abstract

Cyclization of the hydrazide of 5-ethoxycarbonyl-2, 6-dimethylpyridine-3-carboxylic acid by acylation with aromatic or aliphatic acid chlorides with subsequent boiling in POCl 3 or heating in orthoformic acid gave the corresponding ethyl 2, 6-dimethyl-5-(5-R-1, 3, 4- oxadiazol-2-yl) pyridine-3-carboxylate. The cyclization of the reaction products with hydrazine hydrate has been studied. Cyclization of the dihydrazide of 2, 6-dimethyl-3, 5- ...