Letters in Organic Chemistry

A facile method for the synthesis of 3-alkyloxindole

TP Du, GG Zhu, J Zhou

Index: Du, Tai-Ping; Zhu, Gang-Guo; Zhou, Jian Letters in Organic Chemistry, 2012 , vol. 9, # 3 p. 225 - 232

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Citation Number: 5

Abstract

Benzylamine in combination with acetic acid was identified as a powerful catalyst for the condensation of oxindole with aldehydes, acetone or cyclic ketones. A variety of 3- alkyloxindoles could be readily prepared in 10 mmol scale via the sequential benzylamine acetate catalyzed condensation of oxindoles with aldehydes (or ketones) and conjugate reduction by NaBH4.