Synthesis and adrenolytic activity of 1-(1H-indol-4-yloxy)-3-{[2-(2-methoxyphenoxy) ethyl] amino} propan-2-ol and its enantiomers. Part 1
G Groszek, M Bednarski, M Dybała, B Filipek
Index: Groszek, Grazyna; Bednarski, Marek; Dybala, Malgorzata; Filipek, Barbara European Journal of Medicinal Chemistry, 2009 , vol. 44, # 2 p. 809 - 817
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Citation Number: 17
Abstract
The synthesis of (2RS)-1-(1H-indol-4-yloxy)-3-{[2-(2-methoxyphenoxy) ethyl] amino} propan- 2-ol ((RS)-9) and its enantiomers has been described and tested for electrocardiographic, antiarrhythmic, hypotensive and spasmolytic activities as well as for α1-, α2-and β1- adrenoceptors' binding affinities. All compounds significantly decrease systolic and diastolic blood pressure, and possess antiarrhythmic activity and affinity to α1-, α2-and β1- ...
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