Medicinal Chemistry Research

New thiazolidinyl analogs containing pyridine ring: synthesis, biological evaluation and QSAR studies

R Ranga, V Sharma, V Kumar

Index: Ranga, Reetu; Sharma, Vikas; Kumar, Vipin Medicinal Chemistry Research, 2013 , vol. 22, # 4 p. 1538 - 1548

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Citation Number: 4

Abstract

Abstract A series of pyridine derivatives of thiazolidin-4-ones (4a–4o) has been synthesized. Structures of these compounds were established on the basis of elemental analysis, IR, 1 H NMR, 13 C NMR, and Mass spectral data. All the synthesized compounds have been evaluated for their anti-inflammatory and analgesic effects. The results showed that compound 2-[4-methylphenylimino]-5-(1 H-pyridin-2-ylmethylidene)-1, 3-thiazolidin-4-one ...