Novel indole-2-carboxylates as ligands for the strychnine-insensitive N-methyl-D-aspartate-linked glycine receptor

…, BK Cheng, AA Cordi, JP Biesterfeldt…

Index: Gray, Nancy M.; Dappen, Michael S.; Cheng, Brian K.; Cordi, Alexis A.; Biesterfeldt, John P.; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1283 - 1292

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Citation Number: 67

Abstract

Glycine, alanine, and serine (Chart I) have been shown to enhance the electrophysiological response induced by the excitatory amino acid, N-methyl-D-aspartate (NMDA), in cortical neurons from primary cell culture.'This potentiation was shown to be independent of the strychnine-sensitive glycine receptor. 2 A strychnine-insensitive, sodium-independent [3H] glycine recognition site in rat brain has been reported3 and autoradiographic studies have ...