Heterocyclization Reactions of 2-(2-Propynylthio)-4 (1H)-quinazolinone Derivatives when Treated with Electrophilic and Nucleophilic Reagents

…, VI Staninets, VV Pirozhenko, AN Chernega

Index: Zborovskii; Orysyk; Dobosh; Staninets; Pirozhenko; Chernega Chemistry of Heterocyclic Compounds, 2003 , vol. 39, # 8 p. 1099 - 1106

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Citation Number: 9

Abstract

Abstract Reaction of the potassium salt of 2-thioquinazolin-4-one with propargyl halides leads to formation of 2-propargylthioquinazolin-4-one derivatives, which undergo heterocyclization when they are treated with electrophilic or nucleophilic reagents and, depending on the nature of the cyclization agent, leads to formation of tricyclic systems with angular or linear structure.