Anti-nitric oxide production activity of isothiocyanates correlates with their polar surface area rather than their lipophilicity

T Noshita, Y Kidachi, H Funayama, H Kiyota…

Index: Noshita, Toshiro; Kidachi, Yumi; Funayama, Hirokazu; Kiyota, Hiromasa; Yamaguchi, Hideaki; Ryoyama, Kazuo European Journal of Medicinal Chemistry, 2009 , vol. 44, # 12 p. 4931 - 4936

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Citation Number: 17

Abstract

There is increasing demand for novel anti-inflammatory drugs with different mechanisms of action. We synthesized a series of isothiocyanates 2b–h based on 6-(methylsulfinyl) hexyl isothiocyanate (6-MITC) found in the pungent spice Wasabia japonica. Inhibitory activities against in-vitro growth of tumor cells and production of nitric oxide (NO) using the mouse macrophage-like cell line J774. 1 were noted. All isothiocyanates were optimized by ...