Tetrahedron Letters

Mild and regioselective iodination of electron-rich aromatics with N-iodosuccinimide and catalytic trifluoroacetic acid

AS Castanet, F Colobert, PE Broutin

Index: Castanet, Anne-Sophie; Colobert, Francoise; Broutin, Pierre-Emmanuel Tetrahedron Letters, 2002 , vol. 43, # 29 p. 5047 - 5048

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Citation Number: 145

Abstract

However, most of these methods require hazardous or toxic reagents or high reaction temperature for a long reaction time. A combination of N-iodosuccinimide and trifluoromethane sulfonic acid (2–5 equiv.) 12 has been used for the iodination of deactivated aromatics compounds. Iodination of activated aromatic ethers with only N-iodosuccinimide in acetonitrile has been reported more recently. 7 Nevertheless long reaction times (6–24 h) and high reaction temperature ...