A convenient synthesis of 6, 6′-dimethyl-2, 2′-bipyridine-4-ester and its application to the preparation of bifunctional lanthanide chelators
F Havas, M Danel, C Galaup, P Tisnès, C Picard
Index: Havas, Fabien; Danel, Mathieu; Galaup, Chantal; Tisnes, Pierre; Picard, Claude Tetrahedron Letters, 2007 , vol. 48, # 6 p. 999 - 1002
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Citation Number: 18
Abstract
We describe a convenient scalable synthesis of 4-carbomethoxy-6, 6′-dimethyl-2, 2′- bipyridine based on the application of modified Negishi cross-coupling conditions. The use of this building block in the preparation of a number of dissymmetrically 6, 6′-trisubstituted- 2, 2′-bipyridines and of bifunctional lanthanide chelators is also reported.
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