Phenylcinnamides as novel antimitotic agents

BJ Leslie, CR Holaday, T Nguyen…

Index: Leslie, Benjamin J.; Holaday, Clinton R.; Nguyen, Tran; Hergenrother, Paul J. Journal of Medicinal Chemistry, 2010 , vol. 53, # 10 p. 3964 - 3972

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Citation Number: 28

Abstract

Compound 8H is a phenylcinnamide that induces G2/M-phase cell cycle arrest and cell death in cancer cell lines. Here we show that 8H exerts its cytotoxic activity through disruption of microtubule dynamics in vitro and in cell culture. A series of cinnamide derivatives were synthesized and evaluated, and several new compounds were identified that improve on the activity of the parent compound, with IC50 values for induction of cell ...