Chemistry Letters

Convenient and Regioselective Syntheses of 3, 4-Disubstituted. TRIAGL. 3-Pyrrolin-2-one Derivatives Starting from 2-Tosyl-3, 4-Disubstituted Pyrroles.

H Kinoshita, Y Hayashi, Y Murata, K Inomata

Index: Kinoshita, Hideki; Hayashi, Yoshio; Murata, Yasue; Inomata, Katsuhiko Chemistry Letters, 1993 , # 8 p. 1437 - 1440

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Citation Number: 25

Abstract

3, 4-Disubstituted Δ 3-pyrrolin-2-ones were prepared in high yields via 5-tosyl-Δ 3-pyrrolin-2- ones (4) starting from 2-tosylpyrroles regioselectively. The compounds 4 were found to be useful intermediates for the preparation of a variety of Δ 3-pyrrolin-2-one derivatives. The reactions of 4 with various nucleophiles and active methylene compounds bearing an appropriate leaving group are described.

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