Design, synthesis and biological evaluation of 1, 4-dihydrothieno [3′, 2′: 5, 6] thiopyrano [4, 3-c] pyrazole-3-carboxylic amide derivatives as potential estrogen …

R Sun, J Song, SJ Liu, H Zhao, CL Yan, AJ Zhang…

Index: Sun, Rui; Song, Jing; Liu, Si Jie; Zhao, Hui; Yan, Chun Li; Zhang, Ai Jun; Koirala, Diwa; Li, Da Wei; Hu, Chun Chinese Chemical Letters, 2011 , vol. 22, # 3 p. 256 - 259

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Citation Number: 3

Abstract

The estrogen receptor is a target for therapeutic agents for hormone replacement in menopausal women, osteoporosis, reproductive cancers such as breast cancer, uterine cancer and prostate cancer. 1, 4-Dihydrothieno [3′, 2′: 5, 6] thiopyrano [4, 3-c] pyrazole-3- carboxylic amide derivatives were designed, synthesized and biological evaluated as potential estrogen receptor antagonists.