Metabolism of 4-amino-3-hydroxybenzoic acid by Bordetella sp. strain 10d: A different modified meta-cleavage pathway for 2-aminophenols

…, S Takenaka, S Murakami, K Aoki

Index: Orii, Chika; Takenaka, Shinji; Murakami, Shuichiro; Aoki, Kenji Bioscience, Biotechnology and Biochemistry, 2006 , vol. 70, # 11 p. 2653 - 2661

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Citation Number: 2

Abstract

Bordetella sp. strain 10d metabolizes 4-amino-3-hydroxybenzoic acid via 2-hydroxymuconic 6-semialdehyde. Cell extracts from 4-amino-3-hydroxybenzoate-grown cells showed high NAD+-dependent 2-hydroxymuconic 6-semialdehyde dehydrogenase, 4-oxalocrotonate tautomerase, 4-oxalocrotonate decarboxylase, and 2-oxopent-4-enoate hydratase activities, but no 2-hydroxymuconic 6-semialdehyde hydrolase activity. These enzymes involved in ...