Tetrahedron: Asymmetry

Application of pig liver esterase catalyzed transesterification in organic media to the kinetic resolution of glycerol derivatives

M Jungen, HJ Gais

Index: Jungen, Manfred; Gais, Hans-Joachim Tetrahedron Asymmetry, 1999 , vol. 10, # 19 p. 3747 - 3758

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Citation Number: 22

Abstract

The PLE/MPEG catalyzed transesterification of the glycerol ketals rac-1a and rac-1d–f with vinyl propionate in toluene proceeded with good selectivities (E= 24–34) and gave the enantiomerically enriched S-alcohols 1a and 1d–f, and the S-esters 2a and 2d–f. High selectivities (E= 99 and E≥ 200) were observed in the transesterification of the glycerol ether rac-3 and its desoxy analog rac-5, both having a secondary hydroxy group, with PLE ...