Rapid and specific post??synthesis modification of DNA through a biocompatible condensation of 1, 2??aminothiols with 2??cyanobenzothiazole

Y Cheng, H Peng, W Chen, N Ni, B Ke…

Index: Cheng, Yunfeng; Peng, Hanjing; Chen, Weixuan; Ni, Nanting; Ke, Bowen; Dai, Chaofeng; Wang, Binghe Chemistry - A European Journal, 2013 , vol. 19, # 12 p. 4036 - 4042

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Citation Number: 12

Abstract

Abstract Post-synthesis modification of DNA is an important way of functionalizing DNA molecules. Herein, we describe a method that first enzymatically incorporates a cyanobenzothiazole (CBT)-modified thymidine. The side-chain handle CBT can undergo a rapid and site-specific cyclization reaction with 1, 2-aminothiols to afford DNA functionalization in aqueous solution. Another key advantage of this method is the ...