Construction of arene-fused-piperidine motifs by asymmetric addition of 2-trityloxymethylaryllithiums to nitroalkenes: the asymmetric synthesis of a dopamine D1 full …

M Yamashita, K Yamada…

Index: Yamashita, Mitsuaki; Yamada, Ken-Ichi; Tomioka, Kiyoshi Journal of the American Chemical Society, 2004 , vol. 126, # 7 p. 1954 - 1955

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Citation Number: 43

Abstract

The straightforward methodology for the construction of chiral arene-fused-piperidine motifs using a highly enantioselective addition of 2-trityloxymethylaryllithiums to cyclic and acyclic nitroalkenes has been developed. The versatility of the process was highlighted by the first asymmetric synthesis of a dopamine D1 full agonist, A-86929.