European journal of medicinal chemistry

Synthesis and antitumor activity of ureas containing pyrimidinyl group

C Jin, YJ Liang, H He, L Fu

Index: Jin, Chuanfei; Liang, Yong-Ju; He, Hongwu; Fu, Liwu European Journal of Medicinal Chemistry, 2011 , vol. 46, # 1 p. 429 - 432

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Citation Number: 18

Abstract

A novel series of ureas containing pyrimidinyl group were designed and synthesized. Some of the prepared compounds showed potential cytotoxicity against several human cancer cell lines. From the structure-activity relationships we may conclude that introduction of a sulfide bridge between phenyl and pyrimidinyl rings would be critical for their biological activities.