Reactions of some nitrogen heterocycles with chlorodifluoromethane under conditions of phase-transfer catalysis
A Jończyk, E Nawrot, M Kisielewski
Index: Jonczyk, Andrzej; Nawrot, Ewelina; Kisielewski, Michal Journal of Fluorine Chemistry, 2005 , vol. 126, # 11-12 p. 1587 - 1591
Full Text: HTML
Citation Number: 17
Abstract
Aromatic heterocyclic compounds containing one to four nitrogen atoms react with chlorodifluoromethane in the presence of concentrated aqueous sodium hydroxide and a catalyst, benzyltriethylammonium chloride (TEBAC) in dichloromethane or THF (phase- transfer catalysis, PTC) with formation of N-difluoromethyl substituted derivatives. The process takes place by reaction of N-anions from these heterocycles with difluorocarbene ...
Related Articles:
Chlorodifluoromethyl aryl ketones and sulfones as difluorocarbene reagents: The substituent effect
[Wang, Fei; Zhang, Laijun; Zheng, Ji; Hu, Jinbo Journal of Fluorine Chemistry, 2011 , vol. 132, # 8 p. 521 - 528]
[Wang, Fei; Li, Lingchun; Ni, Chuanfa; Hu, Jinbo Beilstein Journal of Organic Chemistry, 2014 , vol. 10, p. 344 - 351]