Gem-diamines as highly active organocatalysts for carbon–carbon bond formation

MJ Climent, A Corma, I Domínguez, S Iborra…

Index: Climent, Maria J.; Corma, Avelino; Dominguez, Irene; Iborra, Sara; Sabater, Maria J.; Sastre, German Journal of Catalysis, 2007 , vol. 246, # 1 p. 136 - 146

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Citation Number: 45

Abstract

Diamines with neighbour nitrogen atoms have been used as base catalysts in the Knoevenagel condensation reaction between benzaldehyde and ethyl cyanoacetoacetate. The catalytic results show that a good basic catalyst requires a combination of two factors: high proton affinity and the ability to return the proton to the oxoanion intermediate. Computational chemistry calculations show this by characterizing the reactants, products, ...