Tetrahedron Letters

Efficient synthesis of unsymmetrical 1, 4-disubstituted-2, 3-diketopiperazines via tandem reductive amination–cyclization

DC Beshore, CJ Dinsmore

Index: Beshore; Dinsmore Tetrahedron Letters, 2000 , vol. 41, # 45 p. 8735 - 8739

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Citation Number: 9

Abstract

Herein we report the efficient syntheses of 1, 4-disubstituted-2, 3-diketopiperazines and 1, 4, 5-trisubstituted-2, 3-diketopiperazines, which feature a tandem reductive amination and acylation. Aliphatic and aromatic primary amines serve as viable nucleophiles under the