Highly Efficient Narasaka–Heck Cyclizations Mediated by P (3, 5??(CF3) 2C6H3) 3: Facile Access to N??Heterobicyclic Scaffolds

A Faulkner, JF Bower

Index: Faulkner, Adele; Bower, John F. Angewandte Chemie - International Edition, 2012 , vol. 51, # 7 p. 1675 - 1679

Full Text: HTML

Citation Number: 39

Abstract

In recent years, the drive for more potent and selective drugs has seen medicinal chemistry move away from “flat” compounds and become increasingly interested in evaluating chiral “3D” drug candidates.[1] The complexities associated with accessing such molecules require the development of more efficient and versatile entries to chiral scaffolds. In this regard, and given the importance of nitrogen,[2] new methods for the efficient and ...

Related Articles:

α??Alkylation of Carbonyl Compounds by Direct Addition of Alcohols to Enol Acetates

[Nishimoto, Yoshihiro; Onishi, Yoshiharu; Yasuda, Makoto; Baba, Akio Angewandte Chemie - International Edition, 2009 , vol. 48, # 48 p. 9131 - 9134]

Molybdenum (II)-and tungsten (II)-catalyzed allylic substitution

[Malkov, Andrei V.; Baxendale, Ian R.; Dvorak, Dalimil; Mansfield, Darren J.; Kocovsky, Pavel Journal of Organic Chemistry, 1999 , vol. 64, # 8 p. 2737 - 2750]

Silver triflate-promoted coupling reactions of benzylic and allylic sulfides with O-silylated enolates of ketones and esters, a synthesis of (±)-ar-turmerone

[Takeda, Kazuyoshi; Torii, Katsumi; Ogura, Haruo Tetrahedron Letters, 1990 , vol. 31, # 2 p. 265 - 266]

Carbon-carbon bond formation in reactions of PhIO. cntdot. HBF4-silyl enol ether adduct with alkenes or silyl enol ethers

[Zhdankin, Viktor V.; Mullikin, Michelle; Tykwinski, Rik; Berglund, Bruce; Caple, Ronald; et al. Journal of Organic Chemistry, 1989 , vol. 54, # 11 p. 2605 - 2608]

Chemistry of carbanions. XX. Comparison of. alpha.-chloro enolate anions and. alpha.-diazo ketones

[House,H.O. et al. Journal of Organic Chemistry, 1971 , vol. 36, # 22 p. 3429 - 3437]

More Articles...