Synthesis and neuroprotective action of xyloketal derivatives in Parkinson's disease models

…, C Shen, W Guo, X Zhang, S Liu, F Liang, Z Xu, Z Pei…

Index: Li, Shichang; Shen, Cunzhou; Guo, Wenyuan; Zhang, Xuefei; Liu, Shixin; Liang, Fengyin; Xu, Zhongliang; Pei, Zhong; Song, Huacan; Qiu, Liqin; Lin, Yongcheng; Pang, Jiyan Marine Drugs, 2013 , vol. 11, # 12 p. 5159 - 5189

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Citation Number: 10

Abstract

Abstract: Parkinson's disease (PD) is the second most common neurodegenerative disease affecting people over age 55. Oxidative stress actively participates in the dopaminergic (DA) neuron degeneration of PD. Xyloketals are a series of natural compounds from marine mangrove fungus strain No. 2508 that have been reported to protect against neurotoxicity through their antioxidant properties. However, their protection versus 1-methyl-4- ...