Catalytic turnover of benzylamine by a model for the lysine tyrosylquinone (LTQ) cofactor of lysyl oxidase

KQ Ling, J Kim, LM Sayre

Index: Ling; Kim; Sayre Journal of the American Chemical Society, 2001 , vol. 123, # 39 p. 9606 - 9611

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Citation Number: 21

Abstract

Lysyl oxidase differs from other copper amine oxidases in that its active quinone cofactor reflects cross-linking of a lysyl residue into the tyrosine-derived quinone nucleus found in the plasma and other copper amine oxidases. A model for the lysyl oxidase cofactor (LTQ), 3, 3- dimethyl-2, 3-dihydroindole-5, 6-quinone (4), was synthesized and found to be stable to both hydrolysis and oxidation events that prevent simpler models from functioning as turnover ...