Proline??Catalyzed Mannich Reaction of Aldehydes with N??Boc??Imines

JW Yang, M Stadler, B List

Index: Yang, Jung Woon; Stadler, Michael; List, Benjamin Angewandte Chemie - International Edition, 2007 , vol. 46, # 4 p. 609 - 611

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Citation Number: 162

Abstract

The catalytic asymmetric Mannich reaction is arguably the most useful approach to synthesize chiral β-amino carbonyl compounds.[1] Six years ago, we discovered a proline- catalyzed version of this powerful reaction.[2] Originally, ketones, aldehydes, and an aniline as the amine component were used in a catalytic asymmetric three-component reaction. Since then, the reaction has found utility in the synthesis of chiral nonracemic nitrogenous ...