Iridium (III)??Catalyzed Approach for the Synthesis of Fused Arenes: Access to Isoindolines, Indanes, and Dihydroisobenzofurans

…, M Ez??Zoubir, S Bompard, MR Vitale, JA Brown…

Index: Auvinet, Anne-Laure; Ez-Zoubir, Mehdi; Bompard, Savinien; Vitale, Maxime R.; Brown, Jack A.; Michelet, Veronique; Ratovelomanana-Vidal, Virginie ChemCatChem, 2013 , vol. 5, # 8 p. 2389 - 2394

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Abstract

Abstract A facile and efficient method for the synthesis of isoindoline, indane, and dihydroisobenzofuran derivatives has been developed through the application of a halogen- bridged iridium (III) complex to the [2+ 2+ 2] cycloaddition of α, ω-diynes with alkynes. The cycloaddition tolerates a broad range of substitution groups, such as alcohol, alkyl, ether, and halogen, and the chemistry can be extended to prepare the corresponding borylated ...

Arylacetamide κ opioid receptor agonists with reduced cytochrome P450 2D6 inhibitory activity

[Le Bourdonnec, Bertrand; Ajello, Christopher W.; Seida, Pamela R.; Susnow, Roberta G.; Cassel, Joel A.; Belanger, Serge; Stabley, Gabriel J.; DeHaven, Robert N.; DeHaven-Hudkins, Diane L.; Dolle, Roland E. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 10 p. 2647 - 2652]

Arylacetamide κ opioid receptor agonists with reduced cytochrome P450 2D6 inhibitory activity

Iridium (III)??Catalyzed Approach for the Synthesis of Fused Arenes: Access to Isoindolines, Indanes, and Dihydroisobenzofurans

Abstract

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