Pyranoside Phosphite–Oxazoline Ligands for the Highly Versatile and Enantioselective Ir-Catalyzed Hydrogenation of Minimally Functionalized Olefins. A Combined …

…, PG Andersson, O Pamies, M Diéguez

Index: Mazuela, Javier; Verendel, J. Johan; Coll, Mercedes; Schaeffner, Benjamin; Boerner, Armin; Andersson, Pher G.; Pamies, Oscar; Dieguez, Montserrat Journal of the American Chemical Society, 2009 , vol. 131, # 34 p. 12344 - 12353

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Citation Number: 80

Abstract

A modular set of phosphite–oxazoline (P, N) ligands has been applied to the title reaction. Excellent ligands have been identified for a range of substrates, including previously challenging terminally disubstituted olefins, where we now have reached enantioselectivities of 99% for a range of substrates. The selectivity is best for minimally functionalized substrates with at least a moderate size difference between geminal groups ...