Synthesis and activity of novel 1-or 3-(3-amino-1-phenyl propyl)-1, 3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors

…, A Vu, E Trybulski, E Koury, G Johnston, J Bray…

Index: Zhang, Puwen; Terefenko, Eugene A.; McComas, Casey C.; Mahaney, Paige E.; Vu, An; Trybulski, Eugene; Koury, Elizabeth; Johnston, Grace; Bray, Jenifer; Deecher, Darlene Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 23 p. 6067 - 6070

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Citation Number: 13

Abstract

A series of novel 1-or 3-(3-amino-1-phenyl propyl)-1, 3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors was discovered. Several compounds such as 15 and 20 showed good hNET potency. Compounds 15 and 20 also displayed excellent selectivity at hNET that appeared superior to those of reboxetine and atomoxetine (4 and 5).