Canadian journal of chemistry

Preparation and reactions of bromo-2-nitro-and bromo-2-aminoimidazoles

SF Farah, RA McClelland

Index: Farah, Salim F.; McClelland, Robert A. Canadian Journal of Chemistry, 1993 , vol. 71, # 4 p. 427 - 432

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Citation Number: 3

Abstract

Treatment of 1-methyl-2-nitroimidazole with bromine in water resulted in rapid dibromination to give 4, 5-dibromo-1-methyl-2-nitroimidazole. In dioxane, the bromination was slower, and could be controlled to give 4-bromo-1-methyl-2-nitroimidazole 5 and 5-bromo-1-methyl-2- nitroimidazole 6 in a 4: 1 ratio. In an attempt to displace the bromine, the monobromo compounds were treated with cysteamine hydrochloride. In each case the nitro group was ...