The Journal of organic chemistry

Dynamic kinetic resolution of 2-oxocycloalkanecarbonitriles: Chemoenzymatic syntheses of optically active cyclic β-and γ-amino alcohols

JR Dehli, V Gotor

Index: Dehli, Juan R.; Gotor, Vicente Journal of Organic Chemistry, 2002 , vol. 67, # 19 p. 6816 - 6819

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Citation Number: 30

Abstract

A series of fungi and yeasts have been tested for the stereoselective bioreduction of 2- oxocycloalkanecarbonitriles, 1. The yeast Saccharomyces montanus CBS 6772 yielded the corresponding cis-hydroxy nitriles, 2, in> 90% ee and de and in high chemical yields. Through simple and efficient procedures, they were transformed into optically active 2-amino and 2-aminomethyl cycloalkanols.

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