Toward the Total Synthesis ofDisorazole A1: Asymmetric Synthesis of the MaskedNorthern Half

…, LO Haustedt, B Niess, PM Schäfer, HMR Hoffmann

Index: Hartung, Ingo V.; Eggert, Ulrike; Haustedt, Lars Ole; Niess, Barbara; Schaefer, Peter M.; Hoffmann, H. Martin R. Synthesis, 2003 , # 12 p. 1844 - 1850

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Citation Number: 7

Abstract

The disorazoles are a family of 29 complex macrodiolides isolatedin 1994 from the fermentation broth of the gliding bacterium Sorangium cellulosum. [1] Disorazole A 1 ,by far the major component of the crude extraction residue, causesbeyond its antifungal activity, decay of microtubules in subnanomolarconcentration, initiates cell cycle arrest in G2/M phaseand competes in vitro with vinblastinfor the tubulin binding site. [2] Structurally,the macrocycle forming hydroxy acids ...