Rational design, synthesis, and evaluation of a new type of PKC inhibitor

…, MA Arai, K Adachi, K Uotsu, M Shibasaki

Index: Sodeoka; Arai; Adachi; Uotsu; Shibasaki Journal of the American Chemical Society, 1998 , vol. 120, # 2 p. 457 - 458

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Citation Number: 20

Abstract

Protein kinase C (PKC), a serine-and threonine-phosphorylating enzyme, is thought to play central roles in cellular signal transductions. 2 To clarify its physiological roles and to serve, potentially, as an important compound in anticancer therapies, a specific PKC inhibitor would be of great use. PKC has a catalytic site that phosphorylates substrate proteins and a regulatory site that controls its kinase activity. Since the catalytic site shares many features ...