Synthesis, biological activity and conformational study of 1, 4-benzoxazine derivatives as potassium channel modulators

G Caliendo, P Grieco, E Perissutti, V Santagada…

Index: Caliendo, Giuseppe; Grieco, Paolo; Perissutti, Elisa; Santagada, Vincenzo; Santini, Antonello; Albrizio, Stefania; Fattorusso, Caterina; Pinto, Aldo; Sorrentino, Raffaella European Journal of Medicinal Chemistry, 1998 , vol. 33, # 12 p. 957 - 967

Full Text: HTML

Citation Number: 31

Abstract

With the aim of discovering new molecules with K+-channel activating properties, we have synthesized derivatives of cromakalim (CRK), an important molecule which shows specific affinity towards K+ channels, by replacing the benzopyrane ring of this reference compound with a 1, 4-benzoxazine moiety. A different number of substituents showing a good discrimination between hydrophobic and electronic properties have been inserted at the 6 ...