Synthesis of new tetracyclic 7-oxo-pyrido [3, 2, 1-de] acridine derivatives

CH Chen, YW Lin, R Kakadiya, A Kumar, YT Chen…

Index: Chen, Ching-Huang; Lin, Yi-Wen; Kakadiya, Rajesh; Kumar, Amit; Chen, Yu-Ting; Lee, Te-Chang; Su, Tsann-Long Tetrahedron, 2011 , vol. 67, # 33 p. 5883 - 5893

Full Text: HTML

Citation Number: 4

Abstract

A series of (±) 3-hydroxyl-and 2, 3-dihydroxy-2, 3-dihydro-7-oxopyrido [3, 2, 1-de] acridines were synthesized for antitumor evaluation. These agents can be considered as analogues of glyfoline or (±) 1, 2-dihydroxyacronycine derivatives. The key intermediates, 3, 7-dioxopyrido [3, 2, 1-de] acridines (15a, b or 24a, b), for constructing the target compounds were synthesized either from 3-(N, N-diphenylamino) propionic acid (14a, b) by treating with ...