Cytotoxic α-halogenoacrylic derivatives of distamycin A and congeners

I Beria, PG Baraldi, P Cozzi, M Caldarelli…

Index: Beria, Italo; Baraldi, Pier Giovanni; Cozzi, Paolo; Caldarelli, Marina; Geroni, Cristina; Marchini, Sergio; Mongelli, Nicola; Romagnoli, Romeo Journal of Medicinal Chemistry, 2004 , vol. 47, # 10 p. 2611 - 2623

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Citation Number: 37

Abstract

The mechanism of action of many antitumor agents involves DNA damage, either by direct binding of the drug to DNA or to DNA-binding proteins. However, most of the DNA- interacting agents have only a limited degree of sequence specificity, which implies that they may hit all the cellular genes. DNA minor groove binders, among which the derivatives of distamycin A play an important role, could provide significant improvement in cancer ...