Synthetic communications

Synthesis of ipratropium bromide–related compounds

I Tsyskovskaia, M Kandil, Y Beaumier

Index: Tsyskovskaia, Irina; Kandil, Mustapha; Beaumier, Yves Synthetic Communications, 2007 , vol. 37, # 3 p. 439 - 446

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Citation Number: 7

Abstract

Synthesis of ipratropium bromide metabolites is described. ... Synthesis of ipratropium bromide metabolites is described. ... Ipratropium bromide, (endo, syn)??(±)??3??(3??hydroxy??1??oxo??2??phenylpropoxy )??8??methyl??8??(1??methylethyl)??8??azoniabicyclo [3.2.1] octane bromide 10, belongs to the group of tropane alkaloids. It is in fact a diastereomer of the N??isopropyl quaternary salt of atropine 8S??ipratropium bromide 18. As depicted in Fig. 1, the isopropyl group in ipratropium ...