ANTINEOPLASTIC AGENTS: IX. N-BENZYL-N-BIS (2-HALOETHYL) AMINES

GR Pettit, DS Blonda…

Index: Pettit,G.R. et al. Canadian Journal of Chemistry, 1963 , vol. 41, p. 2962 - 2968

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Citation Number: 10

Abstract

A number of N-bis (2-chloroethyl) amines and three N-bis (2-iodoethyl) benzylamines have been prepared for cancer chemotherapy studies. The chloro-nitrogen mustards were readily obtained by aluminum chloride-lithium aluminum hydride reduction of the corresponding N- bis (2-chloroethyl) amides. A convenient procedure for converting N-bis (2-chloroethyl)- benzylamine hydrochlorides to N-bis (2-iodoethyl) benzylamine hydroiodides, employing ...