Tetrahedron letters

Microbial reduction of 1-tetralone 2-carboxyesters as a source of new asymmetric synthons

D Buisson, R Cecchi, JA Laffitte, U Guzzi, R Azerad

Index: Buisson, Didier; Cecchi, Roberto; Laffitte, Jean-Alex; Guzzi, Umberto; Azerad, Robert Tetrahedron Letters, 1994 , vol. 35, # 19 p. 3091 - 3094

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Citation Number: 33

Abstract

Abstract The reduction of unsubstituted or methoxy-substituted (±)-2-carboxyethyl-1- tetralones by selected microorganisms affords optically active 1-hydroxy-2-carboxyethyl tetralins which can be used as versatile asymmetric synthons, for example in the preparation of biologically active methoxy-substituted 2R-aminotetralins. 1R, 2R-(cis)-hydroxyesters of high optical purity are obtained with yeast strains, while the use of filamentous fungi leads ...